The aim of the present study was the histological evaluation of Enamel Matrix Derivative (EMD) effectiveness for regeneration of periodontal DEFECTs. EMD activates cementum synthesis, PDL and bone during the maturation stage of follicole. In this research, EMD was used in surgical DEFECTs of premolar teeth in four adult sheep. Muccoperiosteal flap was reflected in buccal site of teeth. The buccal bone plate was removed from mesial to distal in 4 mm depth. After eliminating the cementum by bur and its etching, EMD was applied on exposed dentine and flap was sutured. In opposite sites of those teeth (control sites) the same process was performed without etching. After 100 days, sheep were sacrificed and histological study through light microscopic was performed on black sections of operation sites. The results showed that in test sites, regeneration of cementum and bone was 62/5% and 42/5-50% respectively. But in control sites regeneration of cementum and bone was 37.5% and 32/5-42/5% respectively. Also the migration of junctional epithelium in control sites was 8-10% more than test sites. The important point is that in test sites, cementum was completely attached to undermining dentine. But, in control sites, the gap between cementum and dentine was visible. As a result, this study suggests that EMD promotes periodontal regeneration, and EMD application is a successful achievement in regenerative periodontal therapy.

Statement of Problem: The goal of bone regenerative therapy is to reconstruct the damaged tissues to initial condition, which seems so important in periodontology and implantology. In such therapies, different biomaterials, with some advantages and disadvantages, may by use.Purpose: The aim of this research was to evaluate the quality, bone trabecular density and thickness of newly forming bone as well as foreign body reaction against Biostite®, in comparison with the control group.Material and Methods: In this experimental study the total number of 5 sheep was operated with general anesthesia. At first 10 standard DEFECTs were created in 5x5x5 mm on the left and right edentulous mandibular ridge. Five DEFECTs were randomly treated by Biostite®, the remaining five were considered as controls. After six months, the sheep were sacrificed and the separated DEFECT areas with intact margin were placed in 10% formalin and prepared for histologic and histomorphometric study. To analyze the data, Mann- Whitney U test was used.Results: The mean percentage of new bone formation in Biostite®group was statistically more han the control group (P<0.05). Newly formed bone was vital in both groups which was a combination of lamellar and woven types, however, the thickness and density of new bone in biostite® group was more than the controls. Foreign body reaction was observed in Biostite® group. Conclusion: It is suggested that Biostite® synthetic material can be useful in bone regenerative therapies.

Purpose: To evaluate 10 cases of corneal epithelial DEFECT who were treated with cyanoacrylate glue temporary tarsorrhaphy.Materials & Methods: We used cyanoacrylate glue (razi supper glue) tarsocilliorraphy for the management of patients with corneal persistent epithelial DEFECTs (PED) with several etiologies who did not respond to other commercial treatments such as lubricants, artificial tears and patching. The cyanoacrylate glue was placed on the lateral one third of anterior lamella of lid margin and base of the cilia after preparastion with povidone iodine 5%, patients underwent a 14 days follow up for epithelial DEFECT and tarsocilliorraphy prospectively.Results: 10 patients (8 males, 2 females) aged 52.1 (range: 12-81) years were evaluated prospectively after cyanoacrylate glue tarsocilliorraphy. Tarsocilliorraphy maintained 12.1 (range: 4-20) days and the mean period of epithelial DEFECT healing was 11.2 (range: 3-20) days.Conclusion: We concluded the cyanoacrylate glue tarsocilliorraphy is an effective and safe method for the treatment of corneal persistent epithelial DEFECT (PED) due to neurotrophic ulcer, exposure keratopathy and any epithelial DEFECTs not responded to commercial treatment.

The lingual mandibular bone DEFECT, which is also known as Stafne’s bone DEFECT, is a rare entity commonly affecting the posterior lingual part of the mandible. Although this lesion usually contains normal connective tissue compartments, it may be misinterpreted as tumor like lesions. In this manuscript, based on the density analysis of the CT images and through use of a simplified quantification system, a novel approach has been introduced which attempts to differentiate the benign nature of the DEFECT.

In this paper, after a review on well-known scenario-based methods of SA evaluation, a different approach is introduced to find ARCHITECTURAL DEFECTs. The proposed method at first, elicits the problems threatening the system's success. Then based on the analysis of the problems and probable DEFECTs which could cause the problems, tests are designed and applied to the system in order to find the real DEFECTs specially the ARCHITECTURAL ones. Results show that the proposed method could be use to find those ARCHITECTURAL DEFECTs which may be remained covered after applying the other methods. Therefore, it could be used as a mean to SA testing and also as a complementary mechanism along with well-known SA evaluation methods. The proposed method and its components are presented in a systematic form. An illustration of its application on the architecture of a real system is presented and the results are compared with the results of applying ATAM on the same architecture.

A B S T R A C T Considering the location of vital centers in the heart of the cities, they are more affected by unexpected events. Hence, due to the probability of the loss of existing services and devastating effects on the social organization and the necessity to prepare essential needs of people and military agencies, planning and building the storage for essential items as a replacement for the damaged services are considered a critical factor in social and defensive reliability. This research tries to locate stockpile of essential Items in Mashhad by emphasizing passive defense criteria and analyzing stockpiles of essential items in terms of form communicational structure. The type of research is applied, and the research method is in theoretical discussion and formulation of mental models, descriptive-analytical and information-gathering methods, documents, questionnaires, and interviews. Moreover, the information analysis method is with the IHWP model in GIS software in the locating section. In the section on examining ARCHITECTURAL patterns and forms is content analysis. The research results show that 20.61 percent of Mashhad has an optimal location potential, and 0.94 percent of city also has a favorable potential for location. Also, parts of the north-east and south of the city have the priority for location. The types of spatial organization of the rectangular form, including centralized, four-armed, introverted, and diagonal, were investigated in the architecture department. The centralized form is preferable to other forms for its capacity and access to exits and spatial organization Extended Abstract Introduction As a stockpile of essential items to facilitate the process of activities and to achieve goals, the warehouse plays a vital role in creating this flexibility in organizations. In fact, from the point of view of crisis management, the stockpile of essential items can play a significant role in the supply chain to deal with unforeseen internal or external incidents. Passive defense in the stockpile of essential items refers to measures that do not require expensive and challenging methods and solutions to protect the stockpile of essential items. Furthermore, it can help avoid the substantial expenses of monitoring the entire inventory and increasing non-conformities (such as theft, fire, non-conformity in the inventory and management inspection, fatal accidents, etc.) or reduce this amount. Choosing the form of the stockpile of essential items for essential items with a passive defense approach requires a comprehensive analysis based on defense principles such as hierarchical protection, nationwide coverage, dynamic protection, relative self-sufficiency, and minimum vulnerability. Therefore, in addition to placing this category of stockpile of essential items in Mashhad, the mentioned research also tries to establish a relationship between ARCHITECTURAL forms and principles of defense to reduce vulnerability and improve the level of relief in times of crisis.   Methodology The current type of research is applied, and the research method is descriptive-analytical. In this research, 29 people were interviewed using semi-structured questionnaires and in-depth interviews with urban and passive defense experts. The method of data analysis is quantitative and qualitative. Also, the content analysis method was used to compile and analyze the ARCHITECTURAL forms of the stockpile of essential items of essential items compatible with the principles of passive defense. The fuzzy quantitative model IHWP was exploited in GIS software for placing the stockpile of essential items in the studied sample.   Results and discussion Locating From the overlaying of 10 indicators, distance from the fault, height of buildings, distance from gas lines, distance from high voltage power lines, road width, building density, risk of uses, distance from water transmission lines, population density, and land prone to liquefaction, location in 10 class was conducted that the first and second priority is the north-east and south of Mashhad, which has the most favorable location. In Mashhad, 17.2% of the city area has a very low score, 12.8% low score, 48.37% medium score, 20.61% high score, and 0.94% very high score regarding location desirability.   Architecture According to the previous studies on geometric forms, the suitable form for warehouse design is a simple form that does not have frequent breaks and sharp and vague points to reduce the spatial deviation. Among the geometrical shapes, square and rectangular right-cornered shapes meet the criteria of warehouse design. In the meantime, the rectangle can define joints along its length, each of which is a focal point for concentrating activities and organizing their performance. Additionally, the internal spaces in this form are reasonably defined, which results in the building's overall form being overshadowed. This also makes the surrounding accesses more targeted and focused, ultimately providing more suitable relief during times of crisis. In order to create four types of stockpiles of essential items, A (centralized), B (four arms), C (introverted), and D (polar) were designed, and the way of combining these stockpiles of essential items was expressed and analyzed separately. The research results on accesses and circulation shows that type A covers a population of over 100,000 people, which has the best performance in terms of access to exits and spatial organization and provides services in times of crisis. Therefore, type A, due to the sequence of layers, lines, and expansion on the surface, has the most functional symmetry with the body of the warehouse, and its spatial projection is limited to adapt the shell to the body. Visually, it has the least visibility from a high height. Due to its volume and formal indicators, it has a high level of homogeneity and camouflage with its surrounding environment.   Conclusion The results of placing stockpiles of essential items in Mashhad showed that the northeast and south of the city have a higher talent for establishment. According to the examination of geometric forms, the rectangular form has the most efficiency for warehouse design in the architecture area. Due to formal capabilities such as the value of lines, angles, and proportions, it has the most efficiency in terms of performance, motion circulation, and the least spatial deviation. In order to research as mentioned above, after choosing the dominant form of the rectangle, an attempt has been made to analyze the spatial organization of the rectangular form using linear, combined, decomposition, and combination methods and centripetal and radial arrangements in terms of passive defense principles. Furthermore, four different types of warehouse design were formally analyzed as patterns and representative types, which are four arms, centralized, introverted, and diagonal, each of which, in addition to functional capabilities, also covers the population's needs in crisis conditions. Finally, the concentrated type due to the extent of its successive lines and layers in close proximity to each other, the perceptibility of the surfaces of the body joints because it can be recognized from a high altitude in order not to be identified in times of crisis such as air raid, they have the highest degree of compatibility between function and form from the point of view of passive defense.   Funding There is no funding support.   Authors’ Contribution All of the authors approved the content of the manuscript and agreed on all aspects of the work.     Conflict of Interest Authors declared no conflict of interest.   Acknowledgments We are grateful to all the scientific

2Learning from the values of traditional Iranian architecture and ARCHITECTURAL ornamentation is a way to improve the quality of our today's architecture. The first step of this way is to understand the appropriate method of reading architecture and ARCHITECTURAL ornamentation. In recent decades there are various studies on Iranian ARCHITECTURAL decorations with different methodologies and approaches. This study aims to seek a way of reading ornamentation in Iranian architecture through content analysis of existing studies. So, the main question is: How can we achieve a model for reading, learning, and creating ornamentation in Iranian architecture? In this qualitative research, we have followed an interpretive approach and used a content analysis method to analyze data obtained from a literature review. The results indicate that there are three sources for reading ornamentation: 1. through the examination of the works themselves, 2. the personality of the traditional craftsmen, and 3. reading non-ARCHITECTURAL documents such as cultural sources or literature. There are also eight perspectives to consider ornamentation: 1. historical evolution, 2. ornamentation in a particular type of architecture (mosque, house, bazaar), 3. technical and restoration, 4. semantic-philosophical, 5. materials, 6. colors, 7. patterns, and 8. inscriptions. So, the model of reading and creating Iranian ARCHITECTURAL ornamentation includes four layers; 1. material, 2. color, 3. pattern, and 4. inscription. All the layers together as a system create quality, beauty, and meaning for a place. Literature review shows that few studies have addressed all four of these components in an integrated manner. However, the spatial quality of Iranian architecture is the result of the synergy of all four components. This research suggests a comprehensive method of recognizing and using the four ornamentations by addressing both formal and semantic aspects.